In "The Devil's Dictionary," Ambrose Bierce defined which event as "the first and direst of all disasters"?

Bicycle shorts often contain which spandex fiber, a DuPont trademark introduced in 1958? "Bicycle Wheel", "Fountain" and "Nude Descending a Staircase" are works by which artist? Which auction house held its first sale in London in 1744? On a prescription, the abbreviation "b.i.d." tells you to take a medicine how many times a day? Which word completes both insults "thick as a ___" and "one ___ short of a load"? London and Sault Ste. Marie are cities in which Canadian province? President William McKinley's portrait appeared on which large U.S. bill, last printed in 1945? Which brand's Whitestrips tooth-whitening product first hit store shelves nationally in 2001?