In which year did Columbus first reach the South American mainland, on his third voyage?

Columbia University was founded in 1754 as King's College by royal charter of which English king? Columbus first sighted which Venezuelan river in 1498, though it was not explored until 33 years later? What was the name of Columbus's flagship on his first voyage across the Atlantic? Columbus, Ohio, native Buster Douglas was a 1990 champion in which sport, known as "the sweet science"? Columbus sighted which volcanic Caribbean island in 1493, naming it after a jagged mountain in Spain? Which columnist wrote the 1922 guide "Etiquette", later subtitled "The Blue Book of Social Usage"? Which painter, known for flowers and desert scenes, created "Mule's Skull with Pink Poinsettias"? Complete John Milton's line from "L'Allegro": "Come, and trip it as ye go / On the light ___ toe".